Mastoparan-VT7 |
Mast/stem cell growth factor |
activator caspases |
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[Mas-TRECK mouse]
(an acronym for Mast cell-specific enhancer-mediated Toxin Receptor-mediated Conditional cell Knock out) These transgenic mice (Otsuka et al, 2011; Sawaguchi et al, 2012) have been engineered in a way that the expression of the human diphtheria toxin gene is under the control of an IL4 gene intronic enhancer element that is known to be essential for mast cell-specific IL4 expression. Repeated i.p. treatment of these mice with diphtheria toxin completely depletes mast cells in the skin, peritoneal cavity, stomach and mesenteric windows, and abrogates IgE-dependent passive cutaneous anaphylaxis, passive systemic anaphylaxis (Sawaguchi et al, 2012). Skin
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