Moa |
mob-1 |
BW5147-derived Ts differentiative factor |
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(approved gene symbol) [modulator of apoptosis 1] The gene has been isolated by Tan et al (2001), who named it MAP1 [modulator of apoptosis 1]. MOAP1 is called also PNMA4 [paraneoplastic antigen ma4], a designation based on sequence relationships between a group of neuronal proteins implicated in paraneoplastic neurological disease (Schueller et al, 2005; Wills et al, 2006).
The protein contains BH1 domains, BH2 domains, and BH3 domains and all of them are required for function. Overexpression of MOAP1 in a breast carcinoma cell line induces cell death by apoptosis
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