MMP-21

[matrix metalloproteinase-21] The gene for MMP-21 has been identified together with the gene for MMP-22 in the Cdc2L1-2 locus at the end of the short arm of human chromosome 1, 1p36.3, which is deleted frequently in a number of tumors (Gururajan et al, 1998). The gene has been renamed MMP-23A and its sequence is almost identical with that of MMP-22.

The catalytic domain of MMP-21 is related most closely to MMP-11 (stromelysin-3). The protein does not contain a highly conserved cysteine residue in the proenzyme domain, shown to be involved in the autocatalytic activation of many metalloproteinases ... ... ... ...
 
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Entry last modified: March 2006