MILR1

(approved gene symbol) [mast cell immunoglobulin like receptor 1]. The gene has been identified independently as MCA-32 [mast cell antigen 32]. Alternative designations are C17orf60 [chromosome 17 open reading frame 60], Allergin-1 (Hitomi et al, 2010), allergy inhibitory receptor 1.

MILR1 is an immunoglobulin-like receptor containing an inhibitory ITIM motif (Hitomi et al, 2010). Activation of MILR1 suppresses IgE-mediated, mast cell-dependent responses in mice and humans (Hitomi et al, 2010; Nagai et al, 2013) and also inhibits mast cell activation mediated by TLR2 ... ... ... ...
 
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Entry last modified: December 2016