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[melanoma-associated gene 50] The human melanoma gene, MG50, has been identified by subtractive hybridization in a squamous lung carcinoma cell line, LU-1 (Mitchell et al, 2000). MG50 (1496 amino acids) is a melanoma-associated antigen that is not a differentiation antigen or a mutated protein. MG50 mRNA is found in a variety of melanomas and some other carcinomas. The authors state that it is likely that MG50 is the gene for the IL1 receptor antagonist (IL1ra). However, Weiler et al (1994) have mapped the gene encoding MG50 (D2S448) to human
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