Mevalonate kinase |
Mexikine |
pygmy |
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[MEKK1-related protein X] The approved gene symbol is ZSWIM2 [Zinc finger SWIM domain-containing protein 2]. The protein is being referred to also as ZZZ2 [ZZ-type zinc finger-containing protein 2]
This protein has been identified by Nishito et al (2006). It is expressed uniquely in the testis. MEX is self-ubiquitinated and targeted for degradation through the proteasome pathway. MEX can act as an E3 ubiquitin ligase. Expression of MEX promotes cell death by apoptosis induced through DR3 and DR4 signaling, but not that mediated by BIM-EL or the chemotherapeutic drug adriamycin.
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