MC3T3-G2/PA6 |
MC/9.IL4 |
small inducible cytokine A4-like 1 |
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A murine cell line with characteristics of mast cells that depends on IL3 for its growth and this is blocked by antibodies against IL3 (Nabel et al, 1981) (see also: Factor-dependent cell lines). MC/9 cells are being used as model systems for studies of mast cell biology and biochemistry and to probe roles of mast cells under physiological and pathological conditions. For examples of mice lacking mast cells to probe their functions in vivo see: mast cell-deficient mice.
MC/9 cells also express receptors for IL4 and also proliferate in response to this cytokine. The cell line
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