M918

This cell-penetrating peptide, MVTVLFRRLRIRRACGPPRVRV, has been described by El-Andaloussi et al (2007). M918 is derived from the tumor suppressor protein p14ARF, amino acids 1-22 with positions 3-8 inverted. M918 is non-toxic, does not induce any membrane leakage, and has no antiproliferative effect, and efficiently translocates into various cell types (MCF-7 breast cancer cells, HeLa cells, astrocytoma cells (Hifko), Chinese hamster ovary cells). M918 is more readily internalized into cells than TP10 and penetratin. The peptide is internalized mainly via endocytosis, and in particular macropinocytosis, but independent of ... ... ... ...
 
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Entry last modified: May 2015