luminal cholecystokinin releasing factor |
Lunatusin |
preantral granulosa cells |
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This peptide of 43 amino acids (SKWQHQQDSCRKQLQGVNLTPCEKHIMEKIQGRGDDDDDDDDD) has been isolated from soybean. The protein contains an RGD cell adhesion motif and a conserved region of chromatin-binding proteins (Odani et al, 1987). The protein is encoded by the cotyledon-specific 2S albumin gene (Gm2S-1 protein) (Galvez and de Lumen, 1999).
Lunasin has been shown to prevent cellular transformation by chemical carcinogens and viral oncogenes (Hernández-Ledesma et al, 2009; Galvez et al, 2001; Jeong et al, 2002; Lam et al, 2003) and can inhibit the growth of breast (Hsieh et al, 2010; Hsieh et al, 2010; Pabona et al, 2013), leukemia (De Mejia et al, 2010), colon (Dia and Mejia, 2010), and lung cancer (Inaba et al, 2014)
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