Losac

[Lonomia obliqua Stuart factor activator] This factor has been isolated from bristle extracts of the caterpillar Lonomia obliqua (2006). Exposure to these bristles on skin causes serious hemorrhage and consumptive coagulopathy. Losac is a 45 kDa factor X activator that cleaves the Factor X heavy chain and produces FXa-alpha (Alvarez-FLores et al, 2011). Losac stimulates proliferation of endothelial cells and inhibits cell death by apoptosis induced by serum starvation. Endothelial cells incubated with Losac increase release of nitric oxide and tissue plasminogen activator. Losac also increases slightly the expression of CD55, which protects cells ... ... ... ...
 
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Entry last modified: October 2012