Leishmania S3a-related protein |
leishmanolysins |
APG5L |
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Leishmanolysin is the major surface protein of the parasitic protozoan Leishmania (Etges et al, 1986; Bouvier et al, 1985, 1987). It is a zinc metalloprotease (Etges et al, 1986) and a member of the metzincin family of zinc metalloproteases (Schlagenhauf et al, 1998) The enzyme is known also as PSP [promastigote surface protease], MSP [major surface protease], EC3.4.24.36, or gp63 (Yao et al, 2003).
The enzyme has been shown to be encoded by a family of tandemly linked genes (Button and McMaster 1988, Button et al, 1989) that are expressed differentially during Leishmania development (Yao et al, 2004). Enzymes from different Leishmania species
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