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Leishmanolysin is the major surface protein of the parasitic protozoan Leishmania (Etges et al, 1986; Bouvier et al, 1985, 1987). It is a zinc metalloprotease (Etges et al, 1986) and a member of the metzincin family of zinc metalloproteases (Schlagenhauf et al, 1998) The enzyme is known also as PSP [promastigote surface protease], MSP [major surface protease], EC3.4.24.36, or gp63 (Yao et al, 2003).

The enzyme has been shown to be encoded by a family of tandemly linked genes (Button and McMaster 1988, Button et al, 1989) that are expressed differentially during Leishmania development (Yao et al, 2004). Enzymes from different Leishmania species ... ... ... ... ... Subscribe to continue reading! ... ...


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