LeIF

[Leishmania initiation factor] This protein is encoded in the genome of Leishmania brasiliensis and Leishmania infantum. It is a homolog of eukaryotic ribosomal elongation and initiation factor-4a.

The purified protein strongly stimulates spleen cells from immunodeficient SCID mice to produce IL12, IL18, and high levels of IFN-gamma. LeIF also potentiates the cytotoxic activity of natural killer cells.

The receptor responsible for these activities is not known. TLR4 has been ruled out as a receptor because C3H/HeJ mice used in the studies have a defective TLR4 receptor.

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Entry last modified: January 2004