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LYVE-1

[lymphatic vessel endothelial hyaluronan receptor-1] LYVE-1 is a type 1 integral membrane glycoprotein (322 amino acids) related to CD44 (Banerji et al (1999) that plays an important role in lymphangiogenesis. Sequence analysis shows that LYVE-1 is identical with CRSBP-1 [Cell surface retention sequence binding protein-1].

LYVE-1 has been identified as a major endocytic receptor for the extracellular matrix glycosaminoglycan hyaluronan (Prevo et al, 2001), a key substrate for cell migration in tissues during inflammation, wound healing, and neoplasia. LYVE-1 is expressed on lymph vessel walls and binds soluble and immobilized hyaluronan.

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