LRP4

[low density lipoprotein receptor-related protein 4; LDL receptor-related protein 4]. This protein has been identified independently as KIAA0816 (Okazaki et al, 2003). The protein contains two EGF-like domains and in databanks is being referred to also as MEGF7 (Nakayama et al, 1998) (note that this designation is used also for another unrelated factor, VE-statin).

Mice bearing functional null mutations die perinatally due to a failure of forming neuromuscular junctions (Weatherbee et al, 2006; Zhang et al, 2008; Kim et al, 2008). Johnson et al (2005) have generated knock-out mice that show reduced expression of LRP4. These ... ... ... ...
 
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Entry last modified: January 2010