LMIR6 |
LmjMCA |
miR mimetics |
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[leukocyte mono-Ig-like receptor 7] LMIR7 is expressed highly in mast cells and monocytes / macrophages. Importantly, LMIR7 engagement induces cytokine production in bone marrow-derived mast cells. FcR-gamma deficiency abolishes LMIR7-mediated activation of mast cells, showing that LMIR7 transmits an activating signal through interaction with FcR-gamma. LMIR7 synergizes with TLR4 in signaling (Enomoto et al, 2010). The receptor has been described independently as CLM3 [CMRF35-like molecule-3] and MAIR-VI [myeloid-associated immunoglobulin-like receptor VI]. The receptor belongs to the CD300 family of receptors.
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