LAMC1(139-150) |
LA-MCP-4 |
Hem-2 |
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[LAM cell]
[lymphangioleiomyomatosis cells] These cells are a prominent histologic feature in patients with lymphangioleiomyomatosis, a rare disorder that affects primarily women of child-bearing age. It is characterized by cystic lung destruction, abdominal tumors, and infiltration of the axial lymphatics in the thorax and abdomen (Johnson and Tattersfield, 2002; Taveira-DaSilva et al, 2006).
Lam cells are found in pulmonary and extrapulmonary lesions and are morphologically heterogeneous cells resembling smooth muscle cells (Fukuda et al, 1990; Ferrans et al, 2000). Extrapulmonary LAM cells in the lymphatics are arranged in fascicular and papillary patterns, and are commonly present in lymph nodes of the mediastinum and retroperitoneum (Matsui et al, 2000). LAM cells have been identified also in blood and other
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