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L-TGF

abbr. for latent TGF. The known isoforms of TGF-beta are secreted as latent complexes that contain the growth factor in an inactive form. Binding proteins are required for secretion and association of TGF-beta with the extracellular matrix, which also allows tissue-specific assocviation of the growth factor. Latent TGF-beta consists of a latency-associated peptide (TGF-LAP, which is the TGF-beta propeptide) bound to the 25 kDa TGF-beta by noncovalent interactions. Latent TGF-beta is secreted from cells and deposited into the extracellular matrix as covalent complexes with one of the four known binding proteins (see: ... ... ... ... ... Subscribe to continue reading! ... ...

 

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