Krüppel

(German for "cripple") Krüppel (frequently (mis)spelled Krueppel in English language publications) is a name given to a gene (gene symbol: Kr; gene: CG3340) identified in Drosophila melanogaster embryos. Its absence causes abnormal segmentation and death (Gloor, 1950); Krüppel is crucial for controlling embryogenesis (Schuh et al, 1986).

Krüppel-like factors constitute a family of related transcription factors. A hallmark of this protein family is the presence of a DNA binding motif that contains several (usually three) C2H2 zinc fingers (Philipsen and Suske 1999; Turner and Crossley 1999). The ... ... ... ...
 
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Entry last modified: May 2014