KW-2228

marketed under the names Marograstim and Nartograstim. A recombinant, N-terminally modified form of human G-CSF in which Thr1, Leu3, Gly4, Pro5, and Cys17 are substituted with Ala, Thr, Tyr, Arg, and Ser, respectively. The protein is produced in Escherichia coli.

KW-2228 is more stable than the genuine recombinant factor (see also: Recombinant cytokines, Muteins). It displays a high specific activity, has an increased plasma half-life and improved pharmacokinetic behavior. The factor supports granulopoiesis in the mouse much better than the parent factor. It stimulates the growth of CFU-G in soft agar (see also: ... ... ... ...
 
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Entry last modified: January 2002