KTRNWFSEHFKKVKEKLKDTFA |
KTYFPHFDLSHGSAQVKGHGAK |
ECKR |
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This pentapeptide (Lys-Thr-Thr-Lys-Ser) is derived from the carboxyterminal propeptide of collagen type 1 (COL1A1; collagen-1-alpha-1). This propeptide is cleaved off extracellularly by specific peptidases, and several studies have suggested that N-terminal and C-terminal propeptides may be involved in feedback regulation of collagen biosynthesis (Wiestner et al, 1979; Paglia et al, 1979; Wu et al, 1986: Aycock et al, 1986; Katayama et al, 1991; Fouser et al, 1991) KTTKS constitutes the minimal bioactive sequence of the propeptide (Katayama et al, 1993).
Like the propeptide, KTTKS has been shown to substantially augment extracellular matrix production (Katayama et al, 1991, 1993), stimulating the production of elastin and collagens (specifically collagen type 1, collagen type 3) in a variety of
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