KLKL5KLK |
KLKR |
Cowpox virus crmD |
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abbr. KLKL5KLK. This peptide is an artificial antimicrobial peptide based on a core undecapeptide of sapecin B (Alvarez-Bravo J et al, 1994). The peptide shows potent microbicidal activity against Staphylococcus aureus, Escherichia coli, methicillin-resistant Staphylococcus aureus and Candida albicans in liquid medium. The D-enantiomer of KLKLLLLLKLKamide has been shown to be resistant to tryptic digestion and persists longer in the culture medium, showing greater antimicrobial activity than the original peptide. The KLKLLLLLKLK peptide appears to form numerous channels in bacterial membranes that interfere with membrane functions, resulting in cell death (Alvarez-Bravo et al, 1995).
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