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KDM5B

[KDM5B(+), KDM5B(-), KDM5B(high), KDM5B(low)]

(approved gene symbol) [lysine-specific demethylase 5B]. This protein has been described independently as PLU-1, a gene expressed at high levels in breast cancer cell lines and invasive primary breast carcinomas (Lu et al, 1999) but shows restricted expression in normal human adult tissues (Barrett et al, 2002). The only tissue showing a high expression of PLU1 is testis, where it is expressed in Sertoli cells (Lu et al, 1999).

Yamane et al (2007) have reported that PLU-1 acts as a histone demethylase that directly demethylates Lys-4 of histone H3 ... ... ... ... ... Subscribe to continue reading! ... ...

 

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