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The carboxy-terminal amino acid sequence KDEL (Lys-Asp-Glu-Leu) is a signal for permanent retention of proteins in the endoplasmic reticulum (Munro and Pelham, 1987; Pelham 1988; Ellgard et al, 1999). The KDEL sequence is recognized by a membrane-bound receptor that continually retrieves the proteins from a later compartment of the secretory pathway and returns them to the endoplasmic reticulum (Pelham, 1990).

A variant of The KDEL sequence is RDEL (Arg-Asp-Glu-Leu) (Satoh et al, 1996; Andres et al, 1990). QDEL (Gln-Asp-Glu-Leu), KNEL (Lys-Asn-Glu-Leu), KEDL (Lys-Glu-Asp-Leu), DKEL (Asp-Lys-Glu-Leu), or ... ... ... ... ... Subscribe to continue reading! ... ...


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