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Juxtacrine

A mechanism of growth control and intercellular communication involving specific cell-to-cell contacts. These are established by the interaction of membrane-bound forms of growth factors that are normally secreted, with receptors on an adjacent cell and thus play an important role in developmental processes that have spatial restrictions. Membrane-bound forms of the growth factors then elicit the same spectrum of responses as the soluble factors. On the other hand it is known that the lack of membrane-associated forms of certain factors (for example, SCF; kit ligand) can have pathological consequences despite the presence of a soluble form of the same factor.

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