Jeb receptor |
Jedi-1 |
Bone marrow repopulating cells |
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Jedi (called also Jedi-1) is a transmembrane protein that contains multiple EGF-like repeats. Jedi shares substantial homology with MEGF10 and MEGF11 and is being referred to also as MEGF12 [multiple epidermal growth factor-like domains 12]. The protein has been identified independently as PEAR1 [platelet endothelial aggregation receptor 1], which is also the approved gene symbol. The Drosophila melanogaster homolog has been identified as Draper.
Jedi is thought to be involved in the fine regulation of the early stages of hematopoietic cell differentiation. The gene expressed predominantly in short- and
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