iSCs |
IsCT2 |
OX35 |
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IsCT (named because the scorpion was found in Isalo, Madagascar and the peptide demonstrates cytotoxic activity) is a linear C-terminally amidated peptide of 13 amino acids (ILGKIWEGIKSLFamide) isolated from scorpion Opisthacanthus madagascariensis venom. IsCT possesses antimicrobial activity against Gram-positive bacteria and Gram-negative bacteria and hemolytic activity for sheep red blood cells. The peptide also releases histamine from rat peritoneal mast cells (Dai et al, 2001). IsCT and some of its analogs also show potent cytolytic activity against mammalian and bacterial cells (Lee et al, 2004). The peptide
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