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Intracrine

A mechanism of growth control involving the direct action of cytokines within a cell.

It has been observed that some factors, including bFGF, EGF, NGF and PDGF, produce factor/receptor complexes that are rapidly internalized by the cells and translocated to the nucleus without being degraded. In addition, the activity of some growth factors cannot be inhibited completely by antibodies directed against these factors (see also: UTMC-2 cells).

An intracrine mechanism of growth control would create an internal autocrine ... ... ... ... ... Subscribe to continue reading! ... ...

 

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ENTRY LAST MODIFIED: February 2004



 
 
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