inflamm-ageing |
inflammamiRs |
FAM3B |
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(a compound word derived from inflammation and ageing; sometimes inflamm-ageing) The term inflammaging has been proposed by Franceschi et al (2007) to refer to an age-related progressive low grade chronic pro-inflammatory status (see also: inflammation; see also: metaflammation). Inflammaging renders older subjects more susceptible to a poor prognosis following systemic insults (Franceschi et al, 2000; Nomellini et al, 2009) and is one of the major driving forces of frailty and of common severe age-related diseases (Vasto et al, 2007; Franceschi et al, 2007).
Attributed originally mainly to the progressive activation of immune cells over time, the process can be augmented by cellular senescence, with ageing cells acquiring an
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