Inflammaging

(a compound word derived from inflammation and ageing; sometimes inflamm-ageing) The term inflammaging has been proposed by Franceschi et al (2007) to refer to an age-related progressive low grade chronic pro-inflammatory status (see also: inflammation; see also: metaflammation). Inflammaging renders older subjects more susceptible to a poor prognosis following systemic insults (Franceschi et al, 2000; Nomellini et al, 2009) and is one of the major driving forces of frailty and of common severe age-related diseases (Vasto et al, 2007; Franceschi et al, 2007).

Attributed originally mainly to the progressive activation of immune cells over time, the process can be augmented by cellular senescence, with ageing cells acquiring an ... ... ... ...
 
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Entry last modified: March 2017