ITF

[intestinal trefoil factor] This factor belongs to a family of protease-resistant mucin-associated gastrointestinal peptides (also being referred to as P-domain factors or trefoil factors). These proteins possess a characteristic 3-leaved structure caused by the presence of a sequence motif (designated P-domain or trefoil motif) of 40 amino acids that contains 3 conserved disulfide bonds (Thim, 1989). The three known secreted proteins, TFF-1, TFF-2, TFF-3, are involved in the maintenance or repair of the epithelial mucosa and mainly promote cell migration (see also: Motogenic cytokines) or act as ... ... ... ...
 
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Entry last modified: December 2008