IRp60

[inhibitory receptor protein 60] This inhibitory receptor of 60 kDa contains three inhibitory ITIM motifs in its cytoplasmic tail. The receptor is expressed on all human NK-cells and also on T-cell subsets, monocytes, and granulocytes (Cantoni et al, 1999). Cross-linking of IRp60 by specific monoclonal antibodies strongly inhibits the spontaneous cytotoxicity of NK-cells as well as the NK-cell mediated cytolytic activity induced via different non-HLA-specific or HLA-specific activating receptors. IRp60 associates with the SH2 domain containing phosphatases SHP1 and SHP2.

Sequence analysis shows that this receptor is the same as CLM8 [ ... ... ... ...
 
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Entry last modified: March 2011