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IRF5

[interferon regulatory factor-5] IRF5 is a transcription factor involved in interferon induced signaling. IRF5 stimulates expression of IFN-alpha and inflammatory proteins (RANTES (CCL5), MIP-1-beta (CCL4), MCP-1 (CCL2), IL8, and I-309 (CCL1)) in response to virus infections (Barnes et al, 2001, 2002). IRF5 inhibits the growth of B-cell lymphomas in the absence of wild-type p53 by a mechanism involving G(2)-M cell cycle arrest, and modulation of growth regulatory and pro-apoptotic genes (Barnes et al, 2003).

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