i35-Bregs |
IA4 |
cytotoxicity-dependent APO-1-associated protein 1 |
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I-309 is the name of a cDNA clone encoding a 15-16 kDa glycoprotein of 72 amino acids. The protein contains a third disulfide bond, which leads to significant structural changes in the C-terminal region of the protein (Keizer et al, 2000).
I-309 protein is secreted by T-lymphocytes after cell activation (Miller et al, 1989, 1990). The human I-309 gene, designated SCYA1 (see also: SCY family of cytokines), maps to chromosome 17 (Miller et al, 1990).
I-309 belongs to the family of chemotactic cytokines known as Chemokines. The I-309 and murine TCA-3 or P500 are homologous
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