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IRF10

[interferon regulatory factor-10] see also: IRS (interferon response sequence).

IRF10 is most closely related to IRF4 but differs in both its constitutive and inducible expression. The expression of IRF10 is inducible by interferons and by concanavalin A and requires protein synthesis.

IRF10 is involved in the upregulation of MHC class 1 and guanylate-binding protein, two primary IFN-gamma target genes. It also interferes with the induction of the type I IFN target gene for 2',5'-oligo(A) synthetase.

The expression of IRF10 is not cytotoxic for fibroblasts or B-cells. The expression of IRF10 is induced by the rel oncogene (v-rel and c-rel), and IRF4 ... ... ... ... ... Subscribe to continue reading! ... ...

 

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