ICP27t2 |
ICPP |
primitive hematopoietic progenitor cells |
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[infected cell protein 34.5; Herpes simplex virus ICP34.5 protein] The protein is being referred to also as HSV-1 gamma34.5 protein, herpes simplex virus 1 gamma34.5 protein; gamma(1)34.5 protein
ICP34.5 is encoded by the HSV-1 RL1 gene (Herpes simplex virus RL1 protein) (Chou and Roizman, 1986). ICP34.5 exerts an effect on HSV maturation by controlling the passage of virus through infected cells (Brown et al, 1994). Its expression is required for growth in nondividing cell types such as neurons (Brown et al, 1994). The gene encoding ICP34.5 is responsible for the neurovirulence gene of HSV Chou et al, 1990: Bolovan et al, 1994). ICP34.5 confers neurovirulence by targeting the
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