histatin-12 |
Histidine-proline-rich glycoprotein |
a disintegrin and metalloproteinase with thrombospondin motif-8 |
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Histatins are human histidine-rich and mostly cationic proteins (De Smet and Contreras, 2005) identified originally by Oppenheim et al (1988) as antimicrobial and fungistatic peptides in human parotid and submandibular-sublingual gland secretions. Histatin mRNA appears to be expressed specifically in these glands (Sabatini et al, 1989).
Histatins comprise a family of related proteins. This family comprises
histatin-1 (DSHEKRHHGYRRKFHEKHHSHREFPFYGDYGSNYLYDN) histidine-rich protein-1; abbr. HIS1, HTN1 (approved gene symbol), Hst 1; called also HRP-1 [histidine-rich polypeptide-1]),
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