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Herceptin

also known as Trastuzumab. A recombinant humanized antibody (Genentech, San Francisco, CA) of a murine monoclonal antibody (4D5) directed against HER2 (neu oncogene), which exhibits cytostatic activity on cancer cells that overexpress the HER2 oncogene.

Regimes using herceptin alone or in combination with chemotherapy have been shown to increase survival in patients with metastatic breast cancer and other cancers (Slamon and Pegram, 2001; Pegram et al, 2000). For an overview of its use as a standard treatment in early breast cancer see: Wilson et al (2018)

Herceptin has been shown to inhibit the growth of several cell lines derived from ... ... ... ... ... Subscribe to continue reading! ... ...

 

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