Hepcidin
abbr. HEPC. Hepcidin is a cysteine-rich antimicrobial peptide isolated from human urine and produced in liver hepatocytes (Park et al, 2001; Pigeon et al, 2001). The protein is also referred to as LEAP-1 [liver-expressed antimicrobial peptide, liver-expressed antimicrobial peptide-1] (Krause et al, 2000), or HAMP [Hepcidin antimicrobial peptide]. Kulaksiz et al (2005) have reported that Hepcidin is expressed by renal epithelial cells.
The human HAMP gene encoding hepcidin is a single-copy gene. Mice have two genes, Hamp1 [
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