HPO

[hepatopoietin] This human hepatotrophic factor is involved in liver regeneration. It is found in the conditioned medium of hepatoma cell lines (HepG2, Bel 7402, and SMMC-7721). The gene has been cloned by Yang et al, 1997).

In liver cells, human HPO exists as two isoforms at 15 kDa and 23 kDa (HPO23). The 15 kDa species is located in nucleus, and the 23 kDa species mainly in the cytoplasm (Li et al, 2002). HPO-205 is an isoform of 205 amino acids corresponding to a translated production of 23 kDa (Lu et al, 2002). The protein stimulates DNA synthesis in HepG2 ... ... ... ...
 
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Entry last modified: January 2006