H16 peptide

H16 peptide (Iwasaki et al) is a polyhistidine peptides of 16 histidine residues (HHHHHHHHHHHHHHHH). H16 peptide is a cell-penetrating peptide that shows higher cell-penetrating capacity against HT1080 human fibrosarcoma cells octa-arginine peptide. Cellular uptake of H16 peptide is due mainly to macropinocytosis and most of the H16 peptide localizes in the lysosome and Golgi apparatus. A cytoplasmic pro-apoptotic domain (KLAKLAKKLAKLAK) conjugated to the H16 peptide shows cytotoxic effects. In vivo distribution analysis shows that the H16 peptide is a tumor targeting peptide that accumulates immediately in tumor tissue and is retained up to 132h following injection into the tumor (HT1080 ... ... ... ...
 
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Entry last modified: September 2017