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H16 peptide

H16 peptide (Iwasaki et al) is a polyhistidine peptides of 16 histidine residues (HHHHHHHHHHHHHHHH). H16 peptide is a cell-penetrating peptide that shows higher cell-penetrating capacity against HT1080 human fibrosarcoma cells octa-arginine peptide. Cellular uptake of H16 peptide is due mainly to macropinocytosis and most of the H16 peptide localizes in the lysosome and Golgi apparatus. A cytoplasmic pro-apoptotic domain (KLAKLAKKLAKLAK) conjugated to the H16 peptide shows cytotoxic effects. In vivo distribution analysis shows that the H16 peptide is a tumor targeting peptide that accumulates immediately in tumor tissue and is retained up to 132h following injection into the tumor (HT1080 ... ... ... ... ... Subscribe to continue reading! ... ...


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