GRAIL

[gene related to anergy in lymphocytes] GRAIL is a 66 kDa type 1 transmembrane glycoprotein that localizes to the endocytic pathway and bears homology to RING zinc finger proteins. The protein is known also as RNF128 [RING finger protein 128], which is the approved gene symbol. The protein functions as an E3 Ubiquitin Ligase (Anandasabapathy N et al, 2003).

Role in T-cells

The expression of GRAIL is induced in anergic CD4(+) cells, which are characterized by their inability to produce IL2 and proliferate. GRAIL expression becomes upregulated in the CD4(+) CD25(-) T-cells ... ... ... ...
 
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Entry last modified: August 2023