GPR171

[G-protein-coupled receptor-171] This G-protein-coupled receptor has been identified independently as H963 by Jacobs et al (1997). For a ligand, which plays a functional role in feeding and metabolism, see: ProSAAS.

Gomes et al (2013) have identified GPR171 as the receptor activated by BigLEN that plays a functional role in feeding and metabolism. GPR171 is activated by BigLEN, but not by the C-terminally truncated peptide LittleLEN. The four C-terminal amino acids of BigLEN are sufficient to bind and activate GPR171. Overexpression of GPR171 leads to an increase, and knock-down leads to a decrease, in binding and signaling by BigLEN and the C-terminal ... ... ... ...
 
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