GPR146

[G-protein-coupled receptor-146] This receptor has been identified originally in a search for orthologs of the Rhodopsin family of human G-protein-coupled receptors (Gloriam et al, 2005). Yosten et al (2013) have reported that GPR146 is either the proinsulin C-peptide receptor or an important component of the receptor complex. Stimulation with C-peptide causes internalization of GPR146, and knock-down of GPR146 expression blocks c-fos expression induced by C-peptide in KATOIII gastric cancer cells. Note: there is a controversy about GPR146 being the C-peptide receptor as Lindfors L et al (2020) have not been able to replicate the results reported previously.

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Entry last modified: September 2021