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GPR146

[G-protein-coupled receptor-146] This receptor has been identified originally in a search for orthologs of the Rhodopsin family of human G-protein-coupled receptors (Gloriam et al, 2005). Yosten et al (2013) have reported that GPR146 is either the proinsulin C-peptide receptor or an important component of the receptor complex. Stimulation with C-peptide causes internalization of GPR146, and knock-down of GPR146 expression blocks C-peptide-induced c-fos expression in KATOIII gastric cancer cells.

Richards et al (2014) have reported that erythrocytes express GPR146. The combination of C-peptide and insulin at physiological ratios rescues low oxygen-induced ATP release from ... ... ... ... ... Subscribe to continue reading! ... ...

 

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