GFE-1

This peptide with the sequence CGFECVRQCPERC (Cys-Gly-Phe-Glu-Cys-Val-Arg-Gln-Cys-Pro-Glu-Arg-Cys) has been identified by phage display selection. GFE-1 acts as a lung targeting peptide can selectively bind to mouse lung vasculature after intravenous injection (Rajotte et al, 1998). A second peptide, termed GFE-2 (CGFELETC; Cys-Gly-Phe-Glu-Leu-Glu-Thr-Cys) also shows targeting of lung tissue but to a much lower extent than GFE-1 (Rajotte et al, 1998)

Rajotte D and Ruoslahti (1999) have identified membrane dipeptidase (MDP), a cell surface zinc metalloprotease ... ... ... ...
 
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Entry last modified: June 2015