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GAB3

[GRB2-associated binder 3; GRB2-associated binding protein 3] GAB3 contains an amino-terminal pleckstrin homology domain, multiple potential sites for tyrosine phosphorylation and SH2 domain binding, and two major polyproline motifs potentially interacting with SH3 domains. The protein is a member of a protein family of adaptor and docking proteins involved in multiple signaling pathways initiated by ligands binding to receptors with protein tyrosine kinase activities and other receptors (Liu and Rohrschneider, 2002).

Expression of GAB3 is more restricted than those of the related proteins GAB1 and GAB2 ... ... ... ... ... Subscribe to continue reading! ... ...

 

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