Fibrinogen-beta(15-42)

This peptide, derived from the beta subunit of fibrinogen, is being referred to also as Bbeta(15-42). It is called also FX06.

This bioactive cryptic peptide fragment is a 28 amino acid cleavage product of fibrin. The peptide is released from fibrin E1 fragments by the action of plasmin, following fibrin formation induced by thrombin (Olexa et al, 1981; Smith et al, 1990; Walker and Nesheim, 1999). It represents a sensitive indicator of fibrinolytic activity (Fareed et al, 1998). The peptide is more than a degradation product occurring after fibrin inactivation and is seen now as a bioactive signaling molecule.

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Entry last modified: December 2013