FASN

[Fatty acid synthase; Fatty acid synthetase] abbr. also: FASE. The term SDR27X1 [short chain dehydrogenase/reductase family 27X member 1] is an older synonym.

Fatty acid synthetase (EC2.3.1.85) is an enzyme with multiple catalytic activities located in 7 different, structurally independent domains. It is a key enzyme of de novo lipogenesis that catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH (Wakil, 1989). A complete deficiency of FASN is embryonic lethal, Most of the FASN knock-out embryos die before implantation and heterozygous embryos die ... ... ... ...
 
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Entry last modified: May 2016