Endostar

This is recombinant human endostatin expressed and purified in Escherichia coli. Unlike other recombinant forms of endostatin reported in the literature, Endostar contains an additional sequence (MGGSHHHHH) at the N-terminus. This histidine tag simplifies the purification and improves the stability of the protein (Ling et al, 2007; Song et al, 2005).

It has been approved in China for the treatment of non-small-cell lung cancer. Ling et al (2007) have reported that Endostar suppresses the proliferation, migration, and tube formation of human umbilical vein endothelial cells stimulated by VEGF. Endostar also blocks microvessel sprouting from rat aortic rings in vitro (see: angiogenesis ... ... ... ...
 
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Entry last modified: June 2013