Ea3.17

A murine pre-B-cell line that depends on the continuous presence of IL3 for survival (Gascan et al, 1989) (see also: Factor-dependent cell lines) that is used to assay murine IL3 (see also: bioassays, cytokine assays).

The cells also respond to IL2 and murine or human IL4. The constitutive expression of the myc oncogene in these cells from a recombinant retrovirus increases growth rates in liquid cultures and a higher cloning efficiency in soft agar but does not eliminate the requirement of these cells for ... ... ... ...
 
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Entry last modified: March 2013