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This peptide, termed SP6001 by the authors, has been identified by bioinformatics analysis. The sequence is derived from a DEAH box helicase protein (DHX15 [DEAH box polypeptide 15]) and has been shown to be a potent inducer of endothelial cell apoptosis in the presence of bFGF and VEGF, causing the release of caspase-3 and caspase-7. It also reduces endothelial cell migration (Koshimaki et al, 2012).

SP6001 is potent in reducing tumor angiogenesis when administered i.p. or s.c. in mice bearing xenotransplanted breast cancer cells ... ... ... ... ... Subscribe to continue reading! ... ...

 

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