DSEP

[diffusible survival evasion peptide] This protein has been purified from secretions of oxidatively stressed neural cell lines, murine adenocarcinoma cells, and group A-beta-hemolytic steptococci. The protein has been overexpressed in transgenic mice and human neural cells. Overexpression of the protein allows cells to survive under conditions of severe oxidative stress, in xenocultures when exposed to activated macrophages, and as xenografts in the brain of rats that were not immunosuppressed (Cunningham et al, 2002).

The authors suggest that part of the survival advantage bestowed by overexpression of DSEP may be due to the attenuated response of cells ... ... ... ...
 
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Entry last modified: March 2010